Preparation of Fe3O4-10-HCPT and Fe3O4-HCPT@SiO2 core-shell nanoparticles

Abstract:

To effectively control the dispersion and avoid the aggregate of Fe₃O₄ nanoparticles in the water, the dispersion of Fe₃O₄ nanoparticles was investigated before and after ultrasonic bath in different concentration of NaCl solution. The experimental results showed that the dispersion of Fe₃O₄ nanoparticles was little of aggeregates in the 0.4 mol／L NaCl solution. Furthermore, the magnetic Fe₃O₄-10-Hydroxycamptothecin compounds were prepared by refining pH values of 10-Hydroxycamptothecin system, and then the Fe₃O₄-HCPT@SiO₂ core-shell structural nanoparticles were prepared, of which the diameter of the composite nanoparticle is about 120 nm. The drug release process proves the feasibility of this preparation method.