Motor neurimotor toxicological effect of chlorite on the offspring rats

Abstract:

To evaluate the effect of the byproduct of chlorine dioxide—chlorite on human, the neurimotor toxicological effects of sodium chlorite with the concentrations of 0,0 and 360 mg/L on the offspring rats was studied for three generation by using toxicological tests methods, such as muscle power and brain anatomical observation. The results show that no certain toxicological effect and dose-effect relationship in motor neurimotor system associated with chlorite was detected. Cerebellar lesions occurred in several offspring rat. No observed adverse effect was determined as the concentration is 30 mg/L, and the maximum contaminant level of chlorite in drinking water was 1.1 mg/L.