心室电传导模型的心律失常机制仿真分析

Simulation of arrhythmia mechanism based on ventricular electrical conduction model

摘要:

心律失常是最为常见的心血管疾病,严重的心律失常甚至可能导致患者猝死．浦肯野氏纤维细胞与心室肌细胞的动作电位有很大差异,在许多情况下被认为是严重室性心律失常发生的源头．针对此问题建立了理想化二维心室电传导计算模型来模拟浦肯野氏纤维与心室组织耦合连接以及电兴奋在心脏组织中的传导过程．仿真结果发现虽然浦肯野氏纤维细胞会产生心动过速的电兴奋传导,但也可以抑制极慢或者极快的电兴奋,对心室组织维持正常节律起到重要的保护作用．本模型还可以用于先天性基因变异的心律失常机制以及药物的抗心律失常作用的研究,对心律失常诱发机制研究提供了新的研究手段．

Abstract:

There are great differences in action potentials between the Purkinje fiber cell and ventricular muscle cell. In many conditions, Purkinje-ventricular junction is considered as the source of serious ventricular arrhythmia. An idealized 2D computational model of ventricular electrical conduction is established to simulate the coupling junction of Purkinje fiber and ventricular tissues as well as the excitation conduction in the cardiac tissue. Simulation results show that the Purkinje fiber cells can generate the conduction of electric excitation in tachycardia and also can suppress excitations in extremely slow or fast rhythm. The Purkinje fiber plays an important protective role to keep ventricular tissues in normal rhythm. This model provides a new method to research the mechanism of arrhythmia and also can be used to study arrhythmia induced by congenital gene mutations and effects of antiarrhythmic drugs.