亚氯酸盐对大鼠仔鼠的运动神经毒理学影响

Motor neurimotor toxicological effect of chlorite on the offspring rats

摘要:

为研究二氧化氯在水消毒过程中的主要副产物——亚氯酸盐对人体健康的影响,通过前肌力测试、脑部解剖学观察等运动神经毒理项目的测试等研究手段,研究30、120和 360 mg/L的亚氯酸盐对3代Wistar大鼠仔鼠运动神经系统的毒性．结果表明:亚氯酸钠对Wistar大鼠仔鼠并未表现出明显的毒理学效应和剂量效应关系,但部分360 mg/L剂量组仔鼠小脑发生病变; 对于Wistar大鼠仔鼠运动神经发育无明显副作用的剂量值为30 mg/L,亚氯酸盐在饮用水中的最大污染水平目标值为1.1 mg/L．

Abstract:

To evaluate the effect of the byproduct of chlorine dioxide—chlorite on human, the neurimotor toxicological effects of sodium chlorite with the concentrations of 0,0 and 360 mg/L on the offspring rats was studied for three generation by using toxicological tests methods, such as muscle power and brain anatomical observation. The results show that no certain toxicological effect and dose-effect relationship in motor neurimotor system associated with chlorite was detected. Cerebellar lesions occurred in several offspring rat. No observed adverse effect was determined as the concentration is 30 mg/L, and the maximum contaminant level of chlorite in drinking water was 1.1 mg/L.